Potassium Carbonate → 5-Phenyl-2-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(2-Pyrrolidin-1-ylethoxymethyl)piperidine	HCID 62338872	—
반응물	2-Chloro-5-phenylthieno[2,3-d]pyrimidine	HCID 82104655	—
용매	Acetonitrile	HCID 6342	—
용매	Dichloromethane	HCID 6344	—
생성물	5-Phenyl-2-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine	HCID 89579409	26%

반응 조건

온도	150 °C

반응 단계

2-Chloro-5-phenyl-thieno[2,3-d]pyrimidine (150 mg, 0.61 mmol), 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine (293 mg, 0.92 mmol) and potassium carbonate (253 mg, 1.83 mmol) were combined in acetonitrile (2 mL) and heated in the microwave at 150° C. for 30 minutes. The reaction mixture was diluted with DCM (10 mL), washed with water (10 mL), dried over Na2SO4 and concentrated at reduced pressure. The resulting residue was purified by basic prep HPLC to afford 5-phenyl-2-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidine (67 mg). LCMS [M+H]+=423.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09290511B2
출처 데이터셋	uspto-grants-2016_03
ORD ID	ord-e22e01285f2947b395f3a290516b9fdf
출처 메모	uspto-grants-2016_03