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Tert-butyl 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine-1-carboxylate → 4-(2-Pyrrolidin-1-ylethoxymethyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butyl 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine-1-carboxylate | HCID 89579709 | — |
| 溶媒 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 生成物 | 4-(2-Pyrrolidin-1-ylethoxymethyl)piperidine | HCID 62338872 | 72.9% |
反応手順
Tert-butyl 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine-1-carboxylate (5.28 g, 0.017 moles) was stirred at room temperature in TFA/DCM (1:1, 40 mL) for 1 hour. The solvent was removed at reduced pressure. The resulting residue was purified using an SCX column to afford 4-(2-pyrrolidin-1-ylethoxymethyl)piperidine (2.63 g). LCMS [M+H]+=213.2
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290511B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-fc52f5d4c4c6400fac31c082aa57f79b |
| 出典メモ | uspto-grants-2016_03 |