反应详情

温度

120 °C

A sample of 3-methyl-5-nitropyridin-2-ol (1.44 g, 9.34 mmol) was placed in 35 mL pressure vessel and dissolved in a mixture of toluene/DMF (10:1 ratio; 15 mL). The vessel was capped with a septum, flushed with Argon and phosphorous tribromide (1.32 mL, 14.0 mmol) was added by syringe. The septum cap was replaced by a Teflon cap and the mixture was stirred for 20 min at 120° C. The mixture was cooled to room temperature, neutralized with a 3M NaOH solution and extracted with toluene (3×). The combined organic phases were dried over anhydrous MgSO4 and concentrated under vacuum to give 2.00 g of the desired 2-bromo-3-methyl-5-nitropyridine product as an orange solid (99%).

1. customThe vessel was capped with a septum
2. additionwas added by syringe
3. customThe septum cap
4. customcap
5. temperatureThe mixture was cooled to room temperature
6. extractionextracted with toluene (3×)
7. dry with materialThe combined organic phases were dried over anhydrous MgSO4
8. concentrationconcentrated under vacuum