2,3,4-Trifluoroaniline → N-[[3-[4-[4-cyano-3,3-dimethyl-4-(2,3,4-trifluoroanilino)piperidin-1-yl]-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

HRID 92865Notes

Reaction equation

HRID 92865 reaction equation
[F:1][c:2]1[cH:3][c:4]([N:17]2[C:18](=[O:27])[O:19][CH:20]([CH2:22][NH:23][C:24]([CH3:25])=[O:26])[CH2:21]2)[cH:5][cH:6][c:7]1[N:8]1[CH2:9][C:10]([CH3:15])([CH3:16])[C:11](=[O:14])[CH2:12][CH2:13]1.[F:31][c:32]1[c:33]([NH2:34])[cH:35][cH:36][c:37]([F:40])[c:38]1[F:39].[Na:28][C:29]#[N:30]>>[F:1][c:2]1[cH:3][c:4]([N:17]2[C:18](=[O:27])[O:19][CH:20]([CH2:22][NH:23][C:24]([CH3:25])=[O:26])[CH2:21]2)[cH:5][cH:6][c:7]1[N:8]1[CH2:9][C:10]([CH3:15])([CH3:16])[C:11]([C:29]#[N:30])([NH:34][c:33]2[c:32]([F:31])[c:38]([F:39])[c:37]([F:40])[cH:36][cH:35]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 774682,3,4-TrifluoroanilineHCID 68695641N-[[3-[4-(3,3-dimethyl-4-oxopiperidin-1-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamideHCID 178511850HCID 178511850, compound

Product 1

HCID 68700033N-[[3-[4-[4-cyano-3,3-dimethyl-4-(2,3,4-trifluoroanilino)piperidin-1-yl]-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Sources & evidence

ORD record
ord-fafab84e686f437e8f1978f6926abaf1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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