HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Chlorobenzyl)malonic acid → 2-(4-Fluorobenzyl)malonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Chlorobenzyl)malonic acid | HCID 2785145 | — |
| Reactant | 5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 10880110 | — |
| Reactant | 5-(4-Fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 86096352 | — |
| Product | 2-(4-Fluorobenzyl)malonic acid | HCID 15120643 | — |
Reaction Steps
The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(4-fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 4: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290476B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0f0f7dfd230642ea8809551852c2112a |
| Source note | uspto-grants-2016_03 |