5-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(3-Chlorobenzyl)malonic acid

HRID 928719Notes

Reaction equation

HRID 928719 reaction equation
ClC1C=CC(CC2C(=O)OC(C)(C)OC2=O)=CC=1.BrC1C=C2C(=CC=1)N=C(Cl)C(CC1C=CC(Cl)=CC=1)=C2Cl.[Cl:40][C:41]1[CH:42]=[C:43]([CH:55]=[CH:56][CH:57]=1)[CH2:44][CH:45]1[C:50](=[O:51])[O:49]C(C)(C)[O:47][C:46]1=[O:54]>>[Cl:40][C:41]1[CH:42]=[C:43]([CH:55]=[CH:56][CH:57]=1)[CH2:44][CH:45]([C:46]([OH:54])=[O:47])[C:50]([OH:51])=[O:49]

Participants

4

Reactant 3

HCID 108801105-(4-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 110000795-(3-Chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155806-Bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline3×

Product 1

HCID 212433952-(3-Chlorobenzyl)malonic acid

Procedure

The title compound was prepared by substituting 5-(4-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 3: step a) with 5-(3-chlorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 5: step a) then following the procedure described for the preparation of 2-(4-chlorobenzyl)malonic acid (Intermediate 3: step b).

Sources & evidence

ORD record
ord-827827d021dd42e99b7dabbf0e94f97a
Source dataset
uspto-grants-2016_03
Patent number
US09290476B2

Reaction notes

Loading…