3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline → 3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline

Participants

Role	Name	HCID	Charge
Reactant	3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline	HCID 86715594	—
Reactant	3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline	HCID 86715596	—
Reactant	3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinoline	HCID 86715598	—
Product	3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline	HCID 86715599	—

Reaction Steps

The title compound was prepared by using 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinoline (Intermediate 19: step a) in place of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 6: step c) then following the procedure described for the preparation of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline (Intermediate 16).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09290476B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-35e8a3c00e8946468ea434871f810c01
Source note	uspto-grants-2016_03