3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline → (4-Chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(4-chlorophenyl)methanone

Participants

Role	Name	HCID	Charge
Reactant	3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline	HCID 86715596	—
Reactant	3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinoline	HCID 86715599	—
Reactant	(4-Chlorophenyl)(2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)methanone	HCID 86715602	—
Product	(4-Chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(4-chlorophenyl)methanone	HCID 86715601	—

Reaction Steps

The title compound was prepared by substituting 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 6: step c) with (4-chlorophenyl)(2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)methanone (Intermediate 22: step a) then following the procedure described for the preparation of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline (Intermediate 16).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09290476B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-7fca3fa0efc54a148603269c84b79ceb
Source note	uspto-grants-2016_03