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HRID 928750作成日：2026年10月27日

3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline → 3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-4-chloro-2-methoxyquinoline

https://huagongshe.com/reaction/928750

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinolineHCID 86715591—
反応物3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinolineHCID 86715596—
反応物3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxy-8-methylquinolineHCID 86715599—
生成物3-(Benzo[b]thiophen-2-ylmethyl)-6-bromo-4-chloro-2-methoxyquinolineHCID 86715603—

反応手順

The title compound was prepared by substituting 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 6: step c) with 3-(benzo[b]thiophen-2-ylmethyl)-6-bromo-2,4-dichloroquinoline (Intermediate 10: step c) then following the procedure described for the preparation of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2-methoxyquinoline (Intermediate 16).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290476B2
出典データセットuspto-grants-2016_03
ORD IDord-7e3d2bdab962403c81c92daba58f19bd
出典メモuspto-grants-2016_03