Triethylamine → 6-Chloro-N-methoxy-N-methylnicotinamide

Participants

Reaction Steps

Into a 1000-mL round-bottom flask, was placed methoxy(methyl)amine hydrochloride (12 g, 123.02 mmol), triethylamine (40 g, 395.30 mmol). This was followed by the addition of a solution of 6-chloropyridine-3-carbonyl chloride (17.6 g, 100.00 mmol, Intermediate 37: step a) in dichloromethane (100 mL) dropwise with stirring. The resulting solution was stirred for 12 hours at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum to give the title compound as yellow oil.

Provenance & Evidence