反应详情

温度

105 °C

A heterogeneous mixture of 4-((6-bromo-2,4-dichloroquinolin-3-yl)methyl)benzonitrile (650 mg, 1.16 mmol, Intermediate 44: step c) and sodium methoxide (314 mg, 5.81 mmol) in dry toluene (2.2 mL) was heated at 105° C. After 9 hours, the mixture was cooled to ambient temperature and filtered through Celite®, rinsing with DCM. The filtrate was concentrated and the crude was purified by flash column chromatography (silica gel, 0-5% EtOAc-Hexanes) to provide the title compound as a white solid.

1. temperaturethe mixture was cooled to ambient temperature
2. filtrationfiltered through Celite®
3. washrinsing with DCM
4. concentrationThe filtrate was concentrated
5. customthe crude was purified by flash column chromatography (silica gel, 0-5% EtOAc-Hexanes)