反应详情

温度

80 °C

To a 1 L flask containing 6-bromo-2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinoline (32.5 g, 74.7 mmol, Intermediate 47: step c) was added toluene (550 mL) followed by solid sodium methoxide (40 g, 740 mmol, 97% purity) at room temperature. The suspension was stirred at reflux (˜118° C.) in an aluminum mantle. TLC (50% Hexane-DCM) and HPLC after 5.5 hours showed the reaction to be complete. The reaction mixture was filtered through Celite® while still warm (˜80° C.) and rinsed with warm toluene (˜70° C., 500 mL). The colorless filtrate was concentrated which then solidified to give an off white solid.

1. customthe reaction
2. filtrationThe reaction mixture was filtered through Celite®
3. washrinsed with warm toluene (˜70° C., 500 mL)
4. concentrationThe colorless filtrate was concentrated which
5. customto give an off white solid