反应详情

To a 500 ml flask containing (2,4-dimethylthiazol-5-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol (10.5 g, 46.8 mmol, Intermediate 48: step a) was added 1,4-dioxane (400 mL) and the contents were warmed to form a homogeneous solution. Activated MnO2 (18 g, 207 mmol) was added and the dark brownish mixture was heated to reflux in an aluminum heating mantle under an atmosphere of N2. After 1.5 hours, the contents were filtered while still hot through Celite® and rinsed with warm THF. The resulting light orange solution was concentrated and passed through a silica gel column (25% acetone-DCM) to give the title compound as a light orange solid.

1. temperaturethe contents were warmed
2. customto form a homogeneous solution
3. temperaturethe dark brownish mixture was heated
4. filtrationthe contents were filtered while still hot through Celite®
5. washrinsed with warm THF
6. concentrationThe resulting light orange solution was concentrated