Acetic Anhydride → HCID 86715643, compound

Participants

Reaction Steps

To a solution of (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol (544 mg, 0.960 mmol, Example 77B) in 20 mL of dry DMF at room temperature was added NaH (75 mg, 1.9 mmol, 60% in mineral oil). After stirring for 20 min, acetic anhydride (0.18 mL, 1.9 mmol) was added. The mixture was stirred for one hour and some suspension formed. After the mixture was quenched with a few drops of water, the suspension was filtered off and the filtrate was concentrated in vacuo. The residue was partitioned between dichloromethane and saturated NaHCO3 (aq). The extracts were dried (Na2SO4), filtered, and concentrated to give the title compound as a semi-solid.

Provenance & Evidence