HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Iodosuccinimide → HCID 89705458, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Iodosuccinimide | HCID 120273 | — |
| Reactant | Methyl 4-fluoro-5-((2-fluorophenyl)amino)benzo[d][1, 2,3]thiadiazole-6-carboxylate | HCID 89705382 | — |
| Product | HCID 89705458 | HCID 89705458 | — |
Reaction Steps
Methyl 4-fluoro-5-((2-fluorophenyl)amino)benzo[d][1,2,3]thiadiazole-6-carboxylate can be reacted with halogenations reagent (such as NIS) in the presence of acid at ambient temperature in appropriate solvent. The reaction normally completes within several hours (1-12 h, prefer 3-10 h). Methyl 4-fluoro-5-((2-fluoro-4-iodophenyl)amino)benzo[d][1,2,3]thiadiazole-6-carboxylate is obtained after conventional workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290468B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f5dbc12839c247deb2282f5e0e8e6a0e |
| Source note | uspto-grants-2016_03 |