O-(2-(Vinyloxy)ethyl)hydroxylamine → HCID 89705069, compound

HRID 928920Notes

Reaction equation

HRID 928920 reaction equation
[F:1][C:2]1[C:7]2[N:8]=[N:9][S:10][C:6]=2[CH:5]=[C:4]([C:11](O)=[O:12])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][C:16]=1[F:22].[CH:23]([O:25][CH2:26][CH2:27][O:28][NH2:29])=[CH2:24]>>[F:1][C:2]1[C:7]2[N:8]=[N:9][S:10][C:6]=2[CH:5]=[C:4]([C:11]([NH:29][O:28][CH2:27][CH2:26][O:25][CH:23]=[CH2:24])=[O:12])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([I:21])=[CH:17][C:16]=1[F:22]

Participants

3

Reactant 2

HCID 21867017O-(2-(Vinyloxy)ethyl)hydroxylamineHCID 89705389HCID 89705389, compound

Product 1

HCID 89705069HCID 89705069, compound

Procedure

4-Fluoro-5-((2-fluoro-4-iodophenyl)amino)benzo[d][1,2,3]thiadiazole-6-carboxylic acid can be reacted with O-(2-(vinyloxy)ethyl)hydroxylamine in the presence of coupling reagent in appropriate solvent. The reaction is generally carried out at ambient temperature and normally complete within several hours (1-12 h, prefer 3-10 h). 4-Fluoro-5-((2-fluoro-4-iodophenyl)amino)-N-(2-(vinyloxy)ethoxy)benzo[d][1,2,3]thiadiazole-6-carboxamide is obtained after conventional workup.

Workup

  1. customis generally carried out at ambient temperature
  2. waitnormally complete within several hours
  3. custom(1-12 h, prefer 3-10 h)

Sources & evidence

ORD record
ord-5d19a3234d024ed98832fae9dd830853
Source dataset
uspto-grants-2016_03
Patent number
US09290468B2

Reaction notes

Loading…