HCID 89704786, compound → HCID 89704911, compound

HRID 928922Notes

Reaction equation

HRID 928922 reaction equation
[N:1]([C:4]1[C:19]([O:20]CC2C=CC=CC=2)=[CH:18][C:7]([C:8]([O:10]CC2C=CC=CC=2)=[O:9])=[C:6]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[C:5]=1[F:36])=[N+]=[N-]>[Pd].[Ni]>[NH2:1][C:4]1[C:19]([OH:20])=[CH:18][C:7]([C:8]([OH:10])=[O:9])=[C:6]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[F:35])[C:5]=1[F:36]

Participants

4

Reactant 1

HCID 89704786HCID 89704786, compound

Product 1

HCID 89704911HCID 89704911, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 23938PalladiumCatalyst

Procedure

Benzyl 4-azido-5-(benzyloxy)-3-fluoro-2-((2-fluorophenyl)amino)benzoate can be hydrogenated in the presence of appropriate catalyst (such as Pd/C, Pt, Ni). The reaction normally completes within several hours (1-12 h, prefer 3-10 h). 4-Amino-3-fluoro-2-((2-fluorophenyl)amino)-5-hydroxybenzoic acid is obtained after conventional workup.

Workup

  1. customThe reaction
  2. waitnormally completes within several hours
  3. custom(1-12 h, prefer 3-10 h)

Sources & evidence

ORD record
ord-b491b5efe51c47bda09cad930046c1ae
Source dataset
uspto-grants-2016_03
Patent number
US09290468B2

Reaction notes

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