N-Iodosuccinimide → HCID 89704789, compound

HRID 928923Notes

Reaction equation

HRID 928923 reaction equation
[F:1][C:2]1[C:7]2[N:8]=[CH:9][O:10][C:6]=2[CH:5]=[C:4]([C:11]([OH:13])=[O:12])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21].C1C(=O)N([I:29])C(=O)C1>>[F:1][C:2]1[C:7]2[N:8]=[CH:9][O:10][C:6]=2[CH:5]=[C:4]([C:11]([OH:13])=[O:12])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([I:29])=[CH:17][C:16]=1[F:21]

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 89704884HCID 89704884, compound

Product 1

HCID 89704789HCID 89704789, compound

Procedure

4-Fluoro-5-((2-fluorophenyl)amino)benzo[d]oxazole-6-carboxylic acid can be reacted with halogenations reagent (such as NIS) under acidic condition in appropriate solvent. The reaction generally is carried out at ambient temperature and normally completes within several hours (1-12 h, prefer 3-10 h). 4-Fluoro-5-((2-fluoro-4-iodophenyl)amino)benzo[d]oxazole-6-carboxylic acid is obtained after conventional workup.

Workup

  1. customThe reaction
  2. customgenerally is carried out at ambient temperature
  3. waitnormally completes within several hours
  4. custom(1-12 h, prefer 3-10 h)

Sources & evidence

ORD record
ord-8f01e02a05ef46518bbbe892bc807614
Source dataset
uspto-grants-2016_03
Patent number
US09290468B2

Reaction notes

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