HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoic acid | HCID 59519388 | — |
| Product | Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate | HCID 59519391 | — |
Reaction Steps
5-Bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoic acid can be reacted with MeOH in the presence of SOCl2 in appropriate solvent. The reaction normally completes within several hours (3-12 h, prefer 5-10 h). Methyl 5-bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoate is obtained after conventional workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290468B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-dbaa560b267e478ebddc6d053ee7f5cd |
| Source note | uspto-grants-2016_03 |