HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphine → HCID 89704803, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | 4-Methoxy-alpha-toluenethiol | HCID 80407 | — |
| Reactant | Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate | HCID 59519391 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 89704803 | HCID 89704803 | — |
Reaction Steps
To a solution of methyl 5-bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoate in appropriate solvent is added base under nitrogen atmosphere, followed by Pd catalyst, phosphine ligand and (4-methoxyphenyl)methanethiol. The reaction is generally carried out at high temperature (80-130° C., prefer 90-110° C.) and normally complete within several hours (8-24 h, prefer 12-18 h). Methyl 3,4-difluoro-2-((2-fluorophenyl)amino)-5-((4-methoxybenzyl)thio)benzoate is obtained after conventional workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290468B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-1f857e7e702d413bb9c3d2ddf5f24b96 |
| Source note | uspto-grants-2016_03 |