HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89704777, compound → HCID 89704787, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89704777 | HCID 89704777 | — |
| Catalyst | Nickel | HCID 935 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 89704787 | HCID 89704787 | — |
Reaction Steps
Methyl 4-azido-3-fluoro-2-((2-fluorophenyl)amino)-5-((4-methoxy benzyl)thio)benzoate can be hydrogenated in the presence of appropriate catalyst (such as Pd/C, Pt, Ni) in appropriate solvent. The reaction normally completes within several hours (1-12 h, prefer 3-10 h). Methyl 4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-((4-methoxybenzyl)thio)benzoate is obtained after conventional workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290468B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3bf69afc7d00492993ff5c58e0b1ad0d |
| Source note | uspto-grants-2016_03 |