N-Iodosuccinimide → HCID 89704810, compound

HRID 928930Notes

Reaction equation

HRID 928930 reaction equation
[F:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[C:4]([C:11]([O:13][CH3:14])=[O:12])[C:3]=1[NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22].C1C(=O)N([I:30])C(=O)C1>>[F:1][C:2]1[C:7]2[N:8]=[CH:9][S:10][C:6]=2[CH:5]=[C:4]([C:11]([O:13][CH3:14])=[O:12])[C:3]=1[NH:15][C:16]1[CH:21]=[CH:20][C:19]([I:30])=[CH:18][C:17]=1[F:22]

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 89704808HCID 89704808, compound

Product 1

HCID 89704810HCID 89704810, compound

Procedure

Methyl 4-fluoro-5-((2-fluorophenyl)amino)benzo[d]thiazole-6-carboxylate can be reacted with halogenations reagent (such as NIS) in the presence of acid at ambient temperature in appropriate solvent. The reaction normally completes within several hours (1-12 h, prefer 3-10 h). Methyl 4-fluoro-5-((2-fluoro-4-iodophenyl)amino)benzo[d]thiazole-6-carboxylate is obtained after conventional workup.

Workup

  1. customThe reaction
  2. waitnormally completes within several hours
  3. custom(1-12 h, prefer 3-10 h)

Sources & evidence

ORD record
ord-db6a51040e764201899db95ca7037d75
Source dataset
uspto-grants-2016_03
Patent number
US09290468B2

Reaction notes

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