HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → HCID 89704800, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Hexanoic Acid | HCID 8892 | — |
| Reactant | HCID 131735086 | HCID 131735086 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 89704800 | HCID 89704800 | — |
Reaction Steps
4-Amino-3-fluoro-2-((2-fluorophenyl)amino)-5-((4-methoxybenzyl)thio)benzoate can be deprotected in the presence of acid (such as CF3COOH, HCOOH, CH3COOH and n-C5H11COOH, prefer CF3COOH) at certain temperature (20-75° C., prefer 25-75° C.) in appropriate aromatic aliphatic ether (such as anisole and phenetole, prefer anisole) for some time (1-12 h, prefer 3-10 h). Methyl 4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-mercaptobenzoate is obtained after conventional workup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290468B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-b4b1f67c0f16451c9d0018b974b75fe8 |
| Source note | uspto-grants-2016_03 |