Trifluoroacetic acid → HCID 90067498, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-((4-(2-(((3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-yl)oxy)-6-chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridin-5-yl)phenyl)ethynyl)piperidine-1-carboxylate (147 mg, 0.178 mmol) in anhydrous DCM (2.0 mL) at room temperature was added trifluoroacetic acid (0.2 mL). The reaction was stirred for 2 h at room temperature, and then poured into saturated aqueous sodium bicarbonate (40 mL). The aqueous layer was extracted with ethyl acetate (2×50 mL). The combined organic layers were dried over sodium sulfate, and then concentrated under reduced pressure to afford the title compound as a colorless oil. LC-MS: calculated for C37H53ClN4O5Si2 724.32 observed m/e: 725.32 (M+H)+ (Rt 2.56/4 min).

Provenance & Evidence