反应详情

To a stirring solution of 6-chloro-2-(methylthio)-3H-imidazo[4,5-c]pyridine (954.0 mg, 4.78 mmol) in 50% CH3CN/water (61.4 mL) was added potassium peroxymonosulfate (oxone, 6.46 g, 10.51 mmol). The reaction was stirred under N2 at RT for 15 h, then filtered and the filtrate added to a stirring mixture of EtOAc (1.27 L)/water (0.70 L). The aqueous layer was separated and back-extracted with EtOAc (0.25 L). The combined organic layers were evaporated under reduced pressure to afford the title compound. LC-MS: calculated for C7H6ClN3O2S 230.99 observed m/e: 231.98 (M+H)+ (Rt 1.72/2.0 min)

1. filtrationfiltered
2. additionthe filtrate added to a stirring mixture of EtOAc (1.27 L)/water (0.70 L)
3. customThe aqueous layer was separated
4. extractionback-extracted with EtOAc (0.25 L)
5. customThe combined organic layers were evaporated under reduced pressure