Methyl iodide → HCID 131735092, compound

Participants

Reaction Steps

Iodomethane (40 μl, 0.640 mmol) and sodium hydride (7.7 mg, 0.193 mmol) were added to a stirred solution of (3R,3aR,6R,6aR)-6-[6-chloro-5-(4-phenylphenyl)-1-(2-trimethylsilylethoxymethyl)imidazo[4,5-b]pyridin-2-yl]oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol (35.6 mg, 0.061 mmol) in DMF (0.2 ml). The reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was then partitioned between EtOAc (40 ml), water (10 ml), and 2 N HCl (10 ml). The organic layer was washed with water (2×20 ml) and brine (1×10 ml), dried over MgSO4, filtered, and evaporated under reduced pressure to give a pale amber residue. The residue was dissolved in EtOAc and loaded onto a 500 micron 20 cm×20 cm silica gel plate, which was developed using 70% EtOAc/hexane. The silica containing the product bands was collected and eluted with EtOAc (80 ml). The solvent was evaporated under reduced pressure to give the desired product as a colorless residue. LC-MS: calculated for C31H36ClN3O5Si 593.21 observed m/e: 594.24 (M+H)+ (Rt 1.40/2 min)

Provenance & Evidence