Nitrogen → (3R,3aR,6R,6aR)-6-((6-chloro-5-(3'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

Participants

Reaction Conditions

Reaction Steps

(3R,3aR,6R,6aR)-6-((6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-((2-(trimethyl-silyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol (40 mg, 0.063 mmol) and 1-bromo-3-fluoro-5-methoxybenzene (15.62 mg, 0.076 mmol) in anhydrous dioxane (0.4 ml) was purged with N2 and then chloro[tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II) (6.5 mg, 0.013 mmol) and tripotassium phosphate (0.191 ml, 0.191 mmol) were added under N2 flow. The mixture was heated to 60° C. overnight. Then the crude mixture was extracted with DCM. The combined organic extracts were washed with water and evaporated under reduced pressure. 1 mL of 1:1 CH2Cl2 and TFA was added to the resulting residue and the solution was stirred for 2 h. Then the solvent was evaporated under reduced pressure to give an amber residue. The residue was diluted with 1.5 ml DMSO, filtered and purified by mass directed reverse phase column chromatography eluting with acetonitrile/water+0.1% TFA to give the title product. LC-MS: calculated for C25H21ClFN3O5, 497.12, observed m/e: 498.11 (M+H)+ (RT 1.03/2.00 min)

Provenance & Evidence