反应详情

温度

80 °C

Placed 2-(((3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)-oxy)hexahydrofuro[3,2-b]furan-3-yl)oxy)-6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridine (500 mg, 0.672 mmol), 3,6-dihydro-2H-thiopyran-4-yl trifluoromethanesulfonate (250 mg, 10.8 mmol), and 1M aqueous potassium phosphate tribasic (2.02 ml, 2.02 mmol) under nitrogen in dioxane (7.0 ml). Cooled in dry-ice/acetone bath, pulled a hard vacuum, then introduced nitrogen (3×). Added [1,1′-bis(diphyenylphosphino)ferrocene]dichloropalladium(II) (55 mg, 0.067 mmol) to the frozen mixture, pulled a hard vacuum, then introduced nitrogen (3×). Removed ice bath and stirred mixture at 80° C. for 6 hours. The mixture was cooled to room temperature and poured into saturated aqueous sodium bicarbonate (50 ml). The mixture was extracted with ethyl acetate (2×100 ml), dried over sodium sulfate, and concentrated under reduced pressure. The resultant dark oil was chromatographed using a 40 g silica gel cartridge eluted with 0-40% EtOAc in hexanes over 20 column volumes. The desired product fractions were combined and concentrated under reduced pressure to provide the desired product as a white solid.

1. temperatureThe mixture was cooled to room temperature
2. extractionThe mixture was extracted with ethyl acetate (2×100 ml)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe resultant dark oil was chromatographed
6. washeluted with 0-40% EtOAc in hexanes over 20 column volumes
7. concentrationconcentrated under reduced pressure