反应详情

Toluene (250 mL) was bubbled with nitrogen for 15 min, followed by addition of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (1.0 g, 2.4 mmol) and Pd2(dba)3 (0.5 g, 0.6 mmol). The mixture was bubbled with nitrogen for 15 min, then [1,1′-biphenyl]-2-amine (3.4 g, 20.0 mmol), 4-cyclohexyl-6-iododibenzo[b,d]furan (7.5 g, 20.0 mmol), and sodium tert-butoxide (3.8 g, 40.0 mmol) were added. The mixture was bubbled with nitrogen for 15 min and refluxed for 24 h. After cooling, the reaction mixture was filtered through a silica pad and washed with 50% DCM/hexane. After cooling, the solvent was removed in vacuo and the residue was purified by flash chromatography using 15% DCM/hexane to yield N-([1,1′-biphenyl]-2-yl)-6-cyclohexyldibenzo[b,d]furan-4-amine (8.3 g, 100% yield) as a colorless oil.

1. customToluene (250 mL) was bubbled with nitrogen for 15 min
2. customThe mixture was bubbled with nitrogen for 15 min
3. customThe mixture was bubbled with nitrogen for 15 min
4. temperaturerefluxed for 24 h
5. temperatureAfter cooling
6. filtrationthe reaction mixture was filtered through a silica pad
7. washwashed with 50% DCM/hexane
8. temperatureAfter cooling
9. customthe solvent was removed in vacuo
10. customthe residue was purified by flash chromatography