Sodium Chloride → HCID 86724835, compound

Participants

Reaction Steps

To a solution of 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-3-methyl-1-(1,2,4-triazol-1-yl)butan-2-ol (0.50 g) in 15 mL of THF was added sodium hydride (40 mg) at room temperature. The reaction mixture was then stirred for 30 min followed by the addition of allyl bromide (130 mg) and stirred at room temperature for 18 hours, then at 70° C. for 6 hours and then at 120° C. for 10 hours. An aq. solution of sodium chloride was then added, the mixture was extracted with dichloromethane, dried, evaporated. The crude residue was purified by flash column chromatography on silica gel to give 1-[2-allyloxy-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-3-methyl-butyl]-1,2,4-triazole as a colorless oil (136 mg, 27%; HPLC-MS Rt=1.43 min; masse=432).

Provenance & Evidence