Sodium hydride → HCID 118023214, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of oxazolidin-2-one (0.038 g, 0.44 mmol) in DMF (3 mL) was added NaH (60% dispersion in oil, 0.011 g, 0.44 mmol). The mixture was stirred at a temperature of about 0° C. for 10 minutes, and 3-chloro-N-(3-chloro-1-(pyridin-3-yl)-1H- pyrazol-4-yl)-N-methyl propanamide (0.12 g, 0.40 mmol) was added. The resulting brown-yellow mixture was stirred at room temperature for two hours and diluted with saturated aqueous NH4Cl. The mixture was diluted with EtOAc and saturated aqueous NaCl solution. The organic phase was separated, and the aqueous phase extracted with EtOAc (2×50 mL). The combined EtOAc extracts was dried over MgSO4, filtered, and concentrated under reduced pressure to give light brown gum. The gum was purified on silica gel eluting with MeOH/CH2Cl2 to give the title compound F31 as a colorless oil (0.13 g, 94%).

Provenance & Evidence