2,2-Difluorocyclopropane-1-carboxylic acid → HCID 118023411, compound

Participants

Reaction Steps

To a solution of N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-((2,2-difluoroethyl)amino)-N-ethylpropanamide (0.10 g, 0.28 mmol) in CH2Cl2 (2 mL) were added 2,2-difluoro cyclopropanecarboxylic acid (0.041 g, 0.34 mmol), DMAP (0.034 g, 0.28 mmol) and N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-((2,2-difluoroethyl)amino)-N-ethylpropanamide (0.10 g, 0.28 mmol), and the mixture stirred at room temperature for 2 hours. The mixture was diluted with CH2Cl2 and washed with saturated aqueous NH4Cl and brine, dried over MgSO4, and concentrated under reduced pressure to give pink oil. The residue oil was purified on silica gel eluting with MeOH/CH2Cl2 to give the title compound F34 as a colorless oil (0.079 g, 58%).

Provenance & Evidence