Sodium Hydroxide → HCID 71504395, compound

Participants

Reaction Steps

To a solution of N-(propylsulfonyl)-N-(2,4,5-trifluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide (60 mg, 0.12 mmol, 1 eq.) in MeOH (5 mL) was added NaOH (1N, 0.24 mL, 0.24 mmol, 2 eq.). The resulting mixture was stirred at rt for 1 h, then concentrated. The resulting residue was purified by flash column chromatography (PE/EA=1/1, v/v) to afford N-(2,4,5-trifluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide (31.2 mg, 63.7%). LRMS (M−H+) m/z calculated 408.4, found 408.1. 1H NMR (CDCl3, 400 MHz) δ 8.95-8.99 (dd, 2 H), 8.45 (s, 1 H), 8.38-8.41 (dd, 1 H), 8.27-8.29 (d, 1 H), 7.70-7.77 (m, 1 H), 6.74 (s, 1 H), 3.13-3.17 (m, 2 H), 1.87-1.93 (m, 2 H), 1.06-1.10 (s, 3 H).

Provenance & Evidence