Sodium Carbonate → HCID 86677180, compound

HRID 929355Notes

Reaction equation

HRID 929355 reaction equation
Cl[C:2]1[CH:3]=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([C:12]([N:14]([O:16][CH3:17])[CH3:15])=[O:13])=[CH:7][CH:6]=2.[Cl:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1.C([O-])([O-])=O.[Na+].[Na+]>O1CCOCC1.O>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[CH:3]=[N:4][C:5]3[C:10]([N:11]=2)=[CH:9][C:8]([C:12]([N:14]([O:16][CH3:17])[CH3:15])=[O:13])=[CH:7][CH:6]=3)=[CH:21][CH:20]=1

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 742994-Chlorophenylboronic acidHCID 86677177HCID 86677177, compound

Product 1

HCID 86677180HCID 86677180, compoundYield 61%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 3-chloro-N-methoxy-N-methylquinoxaline-6-carboxamide (5 g, 0.02 mol, 1.0 eq.), (4-chlorophenyl)boronic acid (3.43 g, 0.022 mol, 1.1 eq.) Pd(dppf)2C12 (816 mg, 0.001 mol, 0.05 eq.) and Na2CO3 (4.24 g, 0.04 mol, 2.0 eq.) in dioxane and water (90 mL/10 mL) was heated at 80° C. for 4 hs under N2 protection, then cooled and concentrated. The resulting residue was purified by flash column chromatography (PE/EA=4/1, v/v) to afford 3-(4-chlorophenyl)-N-methoxy-N-methylquinoxaline-6-carboxamide (4 g, 61.0%).

Workup

  1. temperaturecooled
  2. concentrationconcentrated
  3. customThe resulting residue was purified by flash column chromatography (PE/EA=4/1

Sources & evidence

ORD record
ord-180112f28f834902b3e95d645c75ba13
Source dataset
uspto-grants-2016_03
Patent number
US09295671B2

Reaction notes

Loading…