HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hexanethiol → Hexylsulfanylmaleimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hexanethiol | HCID 8106 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 3-bromo-2,5-dihydro-1H-pyrrole-2,5-dione | HCID 11819550 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Hexylsulfanylmaleimide | HCID 66927222 | 100% |
Reaction Steps
To bromomaleimide (300 mg, 1.69 mmol) and sodium acetate (138 mg, 1.69 mmol) in methanol (100 mL) was added hexanethiol (237 μL, 1.69 mmol). After 5 minutes solvent removed in vacuo and purification by flash chromatography (10% ethyl acetate in petroleum ether) afforded hexylsulfanylmaleimide as a cream powder (362 mg, 1.69 mmol) in 100% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09295729B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-1b798eb5a4c84e0d8043d23c7012eefe |
| Source note | uspto-grants-2016_03 |