Indole-3-Acetic Acid → HCID 68277836, compound

Participants

Reaction Steps

To 87.5 mg (0.5 mM) of 3-indolylacetic acid dissolved in dry DMF was added 79 ul (0.5 mM) N,N′-diisopropyl carbodiimide and the mixture was stirred overnight at RT. The solvent was evaporated, the residue was triturated with dry diethyl ether and the crystals formed from DIU were filtered. The flash chromatography from CHCl3 and CHCl3/MeOH 99/1 yielded 91 mg light yellow oil (60%) with Rf=0.82 (CHCl3/MeOH 9/1). The observed mass by LC/MS was 302 for [M+H]+, corresponding to the expected mass of 301.

Provenance & Evidence