HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethoxypropane → (R)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethoxypropane | HCID 6495 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | (R)-4-iodopent-4-ene-1,2-diol | HCID 86667890 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane | HCID 86667889 | — |
Reaction Steps
2,2-Dimethoxypropane and pyridinium p-toluenesulfonate (PPTS) are added to a solution of (R)-4-iodopent-4-ene-1,2-diol in dichloromethane and the mixture stirred at room temperature for 2 hours. Solvents are removed under reduced pressure and the crude product purified by flash chromatography using ethyl acetate/hexane (1:10) eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296686B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-df3d582ce6f64e0897c9dec0bc495a02 |
| Source note | uspto-grants-2016_03 |