反应详情

温度

100 °C

(S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride (1 eq) is dissolved in pyridine and 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-methoxybenzene-1,2-diamine (1 eq) added. The solution is stirred at 100° C. for 2 hours and then partitioned with water and ethyl acetate. The organic layer is washed with brine, dried (MgSO4), concentrated under reduced pressure and purified by flash column chromatography on silica (30% ethyl acetate/hexanes eluant).

1. custompartitioned with water and ethyl acetate
2. washThe organic layer is washed with brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated under reduced pressure
5. custompurified by flash column chromatography on silica (30% ethyl acetate/hexanes eluant)