Water → HCID 11484354, compound

Participants

Reaction Steps

After dissolving compound 20 (300 mg, 0.819 mmol) and 4-chloroaniline (105 mg, 0.819 mmol) in DCM (10 ml), TEA (457 l, 3.28 mmol) was added thereto and the reflux was conducted for 4 hours. After the termination of the reaction, the temperature was reduced to room temperature and water was added thereto. The organic layer was washed with water and water was removed by using anhydrous Na2SO4. After the distillation under the reduced pressure was carried out for the removal of the solvent, column chromatography was conducted to obtain compound 21.

Provenance & Evidence