Ethanesulfonyl chloride → HCID 56971641, compound

Participants

Reaction Steps

Ethylsulfonyl chloride (63 mg, 0.487 mmol) was reacted with PTU (70 mg, 0.244 mmol) as the same manner as the synthesis of 1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea yielding the final product (40 mg, 0.105 mmol, 43% yield). 1H NMR (d6-DMSO, 300 Mhz): δ 8.77 (s, 1H), 7.57 (s, 4H), 6.38 (d, J=7.2 Hz, 1H), 3.63 (m, 1H), 3.52 (d, J=12.3 Hz, 2H), 3.05 (m, 5H), 1.89 (d, J=10 Hz, 2H), 1.47 (m, 2H), 1.22 (t, J=4.8 Hz, 3H).

Provenance & Evidence