Cyclopropanesulfonyl chloride → HCID 56968120, compound

Participants

Reaction Steps

Cyclopropylsulfonyl chloride (75 mg, 0.536 mmol) was reacted with ITU (70 mg, 0.268 mmol) as the same manner as the synthesis of 1-(1-(methylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea yielding the final product (53 mg, 0.145 mmol, 54.1% yield). 1H NMR (d6-DMSO, 300 Mhz): δ 8.20 (s, 1H), 7.26 (d, J=6.9 Hz, 2H), 7.07 (d, J=7.5 Hz, 2H), 6.14 (d, J=7.8 Hz, 1H), 3.59 (m, 1H), 3.52 (d, J=12.8 Hz, 2H), 2.98 (t, J=11.4 Hz, 2H), 2.79 (m, 1H), 2.57 (m, 1H), 1.90 (d, J=12.3 Hz, 2H), 1.42 (m, 2H), 1.15 (d, J=6.6 Hz, 6H), 0.95 (m, 4H).

Provenance & Evidence