4-Phenoxyphenylboronic acid → 5-(tert-Butyl)-2-hydroxy-4'-phenoxy-[1,1'-biphenyl]-3-carbaldehyde

HRID 929557Notes

Reaction equation

HRID 929557 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18](F)(F)F)=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:26]1[C:27](O)=[C:28](C=[C:32](C(C)(C)C)[CH:33]=1)C=O.O(C1C=CC(B(O)O)=CC=1)C1C=CC=CC=1>>[C:1]([C:5]1[CH:6]=[C:7]([CH:23]=[O:24])[C:8]([OH:22])=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:28]=[CH:27][CH:26]=[CH:33][CH:32]=3)=[CH:13][CH:12]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 27343774-Phenoxyphenylboronic acidHCID 71720963-Bromo-5-tert-butyl-2-hydroxybenzaldehyde2×HCID 867187195-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehyde

Product 1

HCID 867187205-(tert-Butyl)-2-hydroxy-4'-phenoxy-[1,1'-biphenyl]-3-carbaldehyde

Procedure

5-(tert-Butyl)-2-hydroxy-4′-phenoxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as an orange oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 4-phenoxyphenylboronic acid.

Sources & evidence

ORD record
ord-8a56cd6f4170443ea25ffa5a70b98332
Source dataset
uspto-grants-2016_03
Patent number
US09296696B2

Reaction notes

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