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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 929562Generated: October 31, 2026

(2,4-Dichlorophenyl)boronic acid → 5-(tert-Butyl)-2',4'-dichloro-2-hydroxy-[1,1'-biphenyl]-3-carbaldehyde

https://huagongshe.com/reaction/929562

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2,4-Dichlorophenyl)boronic acidHCID 2734659—
Reactant3-Bromo-5-tert-butyl-2-hydroxybenzaldehydeHCID 7172096—
Reactant5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehydeHCID 86718719—
Product5-(tert-Butyl)-2',4'-dichloro-2-hydroxy-[1,1'-biphenyl]-3-carbaldehydeHCID 86718724—

Reaction Steps

5-(tert-Butyl)-2′,4′-dichloro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 2,4-dichlorophenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296696B2
Source datasetuspto-grants-2016_03
ORD IDord-7fe017638ad9416d97f837488a05af87
Source noteuspto-grants-2016_03