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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 929569Generated: November 2, 2026

3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 86718733, compound

https://huagongshe.com/reaction/929569

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 2734660—
Reactant3-Bromo-5-tert-butyl-2-hydroxybenzaldehydeHCID 7172096—
Reactant5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehydeHCID 86718719—
ProductHCID 86718733HCID 86718733—

Reaction Steps

5-(tert-Butyl)-3′-chloro-4′-fluoro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 3-chloro-4-fluorophenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296696B2
Source datasetuspto-grants-2016_03
ORD IDord-458bfcab793d4e6aa98c12345dcecb4b
Source noteuspto-grants-2016_03