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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 929578Generated: October 31, 2026

3,4-Difluorobenzeneboronic acid → HCID 86718742, compound

https://huagongshe.com/reaction/929578

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Difluorobenzeneboronic acidHCID 2734337—
Reactant3-Bromo-5-tert-butyl-2-hydroxybenzaldehydeHCID 7172096—
Reactant5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehydeHCID 86718719—
ProductHCID 86718742HCID 86718742—

Reaction Steps

5-(tert-Butyl)-3′,4′-difluoro-2-hydroxy-[1,1′-biphenyl]-3-carbaldehyde was prepared as a yellow oil using the procedure described in Intermediate 5 from 3-bromo-5-(tert-butyl)-2-hydroxybenzaldehyde (Intermediate 4) and 3,4-difluorophenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296696B2
Source datasetuspto-grants-2016_03
ORD IDord-7ee78b5e01e44f7bb78d5f301fca0e2c
Source noteuspto-grants-2016_03