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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 929579Generated: October 31, 2026

3,4-Dichlorobenzeneboronic acid → 3',4'-Dichloro-5-(trifluoromethyl)-[1,1'-biphenyl]-2-ol

https://huagongshe.com/reaction/929579

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Dichlorobenzeneboronic acidHCID 2734330—
Reactant2-Bromo-4-(trifluoromethyl)phenolHCID 2761168—
Reactant5-(Tert-butyl)-2-hydroxy-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carbaldehydeHCID 86718719—
Product3',4'-Dichloro-5-(trifluoromethyl)-[1,1'-biphenyl]-2-olHCID 86718743—

Reaction Steps

3′,4′-Dichloro-5-(trifluoromethyl)-[1,1′-biphenyl]-2-ol was prepared as a yellow oil using the procedure described in Intermediate 5 from 2-bromo-4-(trifluoromethyl)phenol (Tetrahedron 2003, 59, 6545) and 3,4-dichlorophenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296696B2
Source datasetuspto-grants-2016_03
ORD IDord-b6850eb4447d459da981da70449c2aeb
Source noteuspto-grants-2016_03