Formaldehyde → HCID 86718774, compound

Participants

Reaction Steps

To a mixture of 2-phenylphenol (17.0 g, 0.1 mol) and paraformaldehyde (15.0 g, 0.5 mol) in isopropanol (100 mL) was added tert-butylamine (36.5 g, 0.5 mol) dropwise. The resulting reaction mixture was refluxed under nitrogen overnight. The cooled reaction mixture was then concentrated under reduced pressure to give a yellow oil. The yellow oil was dissolved in ethyl acetate to form a solution which was washed with water, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 3-(tert-butyl)-8-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine (30 g) as yellow oil.

Provenance & Evidence