Formaldehyde → HCID 86718784, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of paraformaldehyde (235 mg, 7.83 mmol) and tert-butylamine (0.83 mL, 7.83 mmol) in 1-propanol (5 mL) was heated at 80° C. under nitrogen for 2 hours. A solution of 2,6-bis(4-chlorophenyl)pyridin-3-ol (420 mg, 1.33 mmol) in 1-propanol (5 mL) was then added and the reaction mixture refluxed for 6 days. The reaction mixture was cooled to room temperature, stood for 24 hours and filtered to afford 3-(tert-butyl)-6,8-bis(4-chlorophenyl)-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazine (135.8 mg, 25% yield) as an orange crystalline solid.

Provenance & Evidence