Sodium Carbonate → HCID 178489509, compound

Participants

Reaction Conditions

Reaction Steps

The preparation was carried out analogously to Example 56, using 0.200 g (0.506 mmol) N-(3-bromopyridin-2-yl)-N′-(2-methoxybenzyl)guanidine acetate, 0.092 g (0.759 mmol) phenylboric acid, 0.165 g (1.518 mmol) sodium carbonate, and 0.040 g (0.035 mmol) tetrakis-(triphenylphosphine)palladium(0). The mixture was likewise heated in a reaction block at 110° C., first for 21 hr and then for an additional 20 hr, for a total of 41 hr under a nitrogen atmosphere. After appropriate workup and purification via preparative HPLC, 32 mg pure N-(2-methoxybenzyl)-N′-(3-phenylpyridin-2-yl)guanidine was obtained in the form of the acetate salt (base/acetate in a ratio of 1:1.2).

Provenance & Evidence