反应详情

温度

120 °C

The preparation was carried out analogously to Example 86, using 0.128 g (0.316 mmol) N-(5-iodopyridin-2-yl)-N′-(2-methoxybenzyl)guanidine, 0.097 g (0.511 mmol) [4-(trifluoromethyl)phenyl]boric acid, 0.112 g (1.052 mmol) sodium carbonate, and 0.022 g (0.019 mmol) tetrakis-(triphenylphosphine) palladium(0). The mixture was likewise heated for 60 min at 120° C. in a CEM microwave (230 watts). After filtration and purification via preparative HPLC, 33 mg N-(2-methoxybenzyl)-N′-{5-[4-(trifluoromethyl)phenyl]pyridin-2-yl}guanidine was isolated, a portion of which was present in the form of the acetate salt (base/acetate in a ratio of 1:0.6).

1. filtrationAfter filtration and purification via preparative HPLC